The key COVID-19 findings in me/cfs, distilled into a clear, readable brief. The evidence is here whenever you want to go deeper.
INSIDE THIS MONITOR
37cited sources
4available findings
Study findings updated
AI-assisted evidence summary. For general information. These findings are not individual medical advice or a clinician endorsement.
THE SHORT VERSION
What’s worth knowing.
The key findings, what they mean, and the context that matters.
THE HEADLINE TAKEAWAY50%
Meta-analysis reported 50% of Long COVID patients met ME/CFS criteria
The cited meta-analysis reported that 50% of Long COVID patients met ME/CFS diagnostic criteria.
The diagnostic criteria and assessment timing are unavailable in this summary. The accompanying ME/CFS incidence increase has no named reference group here, so its magnitude is not interpreted.
See the evidence
Of Long COVID patients meet ME/CFS diagnostic criteria
50%
Jason et al., Vernon et al.. Meta-analysis. 2023.
Study-specific findings. Different populations, treatments and follow-up periods can produce different results.
THE RESEARCH, AS IT ARRIVES
Latest studies.
The newest findings added to this collection. The learning from each, already distilled.
Study summaries are not available in this collection yet. The original evidence remains accessible in each monitor.
Dates show when findings were added here, not when papers were published. Study populations and comparisons differ.
WHEN YOU WANT TO GO DEEPERSee all 4 findingsOriginal results, comparisons and study details.
3 of 3 source groupsFindings stay together with their study.
SOURCE 012 findings
NIH RECOVER Initiative. Post-acute sequelae of SARS-CoV-2 infection (PASC): Findings from the RECOVER-Adult cohort. JAMA. 2024;331(5):419-431.
Raj SR, Arnold AC, Barboi A, et al. Long-COVID postural tachycardia syndrome: an American Autonomic Society statement. Clinical Autonomic Research. 2021;31:365-368.
Raj SR, Arnold AC, Barboi A, et al. Long-COVID postural tachycardia syndrome: an American Autonomic Society statement. Clinical Autonomic Research. 2021;31:365-368.
Komaroff AL, Lipkin WI. Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome. Trends in Molecular Medicine. 2021;27(9):895-906.
Jason LA, Islam MF, Conroy K, et al. COVID-19 symptoms over time: Comparing long-haulers to ME/CFS. Fatigue: Biomedicine, Health & Behavior. 2023;11(2):104-118.
Vernon SD, Hartle M, Sullivan K, et al. Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Work. 2023;74(4):1179-1186.
Kedor C, Freitag H, Meyer-Arndt L, et al. A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany. Nature Communications. 2022;13:5104.
Naviaux RK, Naviaux JC, Li K, et al. Metabolic features of chronic fatigue syndrome. Proceedings of the National Academy of Sciences. 2016;113(37):E5472-E5480.
Fedorowski A, Sutton R. Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome. Nature Reviews Cardiology. 2023;20:281-282.
Nakatomi Y, Mizuno K, Ishii A, et al. Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study. Journal of Nuclear Medicine. 2014;55(6):945-950.
Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006;333(7568):575.
Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. National Academies Press. 2015.
Original source link unavailable
[21]
Carruthers BM, van de Sande MI, De Meirleir KL, et al. Myalgic encephalomyelitis: International Consensus Criteria. Journal of Internal Medicine. 2011;270(4):327-338.
Wong TL, Weitzer DJ. Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - A Systemic Review and Comparison of Clinical Presentation and Symptomatology. Medicina (Kaunas). 2021;57(5):418.
VanElzakker MB, Brumfield SA, Lara Mejia PS. Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods. Frontiers in Neurology. 2024;15:1379385.
Hampshire A, Chatfield DA, MPhil AM, et al. Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort. eClinicalMedicine. 2024;47:101417.
Chen C, Haupert SR, Zimmermann L, et al. Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review. Journal of Infectious Diseases. 2022;226(9):1593-1607.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM. Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study. The Lancet. 2022;400(10350):452-461.
Lim EJ, Son CG. Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Journal of Translational Medicine. 2020;18:289.
This is an AI-assisted evidence summary, not a clinician endorsement. Read each original paper for its complete methods, population and limitations. Different studies can ask different questions and report different kinds of results.
Dates marked “added” describe when a finding entered this monitor, not when the study was published or clinically reviewed. Personal health and treatment decisions belong in a conversation with a qualified clinician.